Formate metabolic process

Across TCGA patient cohorts, RNA activity of the Formate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABRACL, GCOM1, and MYZAP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formate metabolic process activity versus ABRACL in BRCA (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABRACL →	-0.653	-0.317	<.001	<.001	3	3
HNSC	GCOM1 →	+0.991	+0.683	<.001	<.001	3	3
HNSC	MYZAP →	+0.749	+0.934	<.001	<.001	3	3
HNSC	CYSRT1 →	+1.682	+0.690	.003	.001	3	2
CCRCC	GNAI2P2 →	-0.091	-0.464	.003	.001	3	2
BRCA	KAT2A →	+1.013	+0.439	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015942 vs ABRACL — BRCA

Explore this scatter interactively →