Formate metabolic process

Across TCGA cell cohorts, RNA activity of the Formate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IK, PCNA, and TBC1D4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IK grouped by Formate metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IK →	-0.737	-1.557	.001	<.001	3	4
STOMACH	PCNA →	+0.773	+1.294	<.001	.001	3	4
BLOOD_Myeloma	TBC1D4 →	+1.557	+1.387	.005	<.001	3	4
BLOOD_Lymphoma	SARS1 →	-0.827	-0.369	.003	<.001	3	3
LUNG_SCLC	ARFGEF3 →	+2.171	+1.289	<.001	<.001	3	3
LUNG_SCLC	TTC9 →	+1.216	+0.906	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IK by Formate metabolic process activity — LUNG_SCLC

Explore this box plot interactively →