Nucleobase-containing compound transport

Across TCGA cell cohorts, RNA activity of the Nucleobase-containing compound transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED3, ZNF286B, and BLVRB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing compound transport activity versus TMED3 in BREAST (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMED3 →	-1.017	-0.220	<.001	<.001	3	8
BLOOD_Leukemia	ZNF286B →	+1.272	+0.113	<.001	<.001	3	7
BREAST	BLVRB →	-1.965	-0.163	<.001	<.001	3	7
CNS	MYDGF →	-0.886	-0.191	.001	.001	3	6
STOMACH	FSD1 →	+3.417	+0.206	<.001	.004	3	6
BREAST	SLC37A1 →	-1.675	-0.152	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015931 vs TMED3 — BREAST

Explore this scatter interactively →