Sterol transport

Across TCGA patient cohorts, RNA activity of the Sterol transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES1, RPL5, and MAOA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sterol transport activity versus CES1 in BRCA (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CES1 →	+1.070	+0.034	<.001	<.001	3	6
OV	RPL5 →	-0.290	-0.041	<.001	<.001	3	6
BRCA	MAOA →	+0.569	+0.016	.002	.003	3	6
OV	SRRM2_S1132 →	-0.561	-0.029	<.001	<.001	3	6
GBM	PRPF40A →	-0.259	-0.034	.001	.001	3	6
BRCA	ESD →	+0.313	+0.023	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015918 vs CES1 — BRCA

Explore this scatter interactively →