Sterol transport

Across TCGA patient cohorts, RNA activity of the Sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP4, CAMK2N1, and LIN9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sterol transport activity versus BMP4 in OV (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BMP4 →	+1.381	+0.216	.001	<.001	3	4
OV	CAMK2N1 →	+1.627	+0.245	<.001	<.001	3	4
OV	LIN9 →	-0.693	-0.225	<.001	<.001	3	4
OV	DSCR9 →	-0.334	-0.171	.002	.001	3	4
BRCA	FOXP4-AS1 →	-0.837	-0.156	<.001	<.001	3	4
OV	SMIM3 →	+1.112	+0.167	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015918 vs BMP4 — OV

Explore this scatter interactively →