Sterol transport

Across TCGA cell cohorts, RNA activity of the Sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOE, SMIM1, and TMEM150A, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sterol transport activity versus APOE in LIVER (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	APOE →	+4.431	+0.083	<.001	.002	3	11
BLOOD_Leukemia	SMIM1 →	+2.181	+0.050	<.001	<.001	3	10
LUNG_SCLC	TMEM150A →	+1.218	+0.051	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	ABCA7 →	+1.219	+0.058	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	THEMIS2 →	+1.556	+0.072	.003	.004	3	9
KIDNEY	PSAP →	+1.170	+0.044	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015918 vs APOE — LIVER

Explore this scatter interactively →