Aminophospholipid transport

Across TCGA patient cohorts, RNA activity of the Aminophospholipid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRSF9_S204, GPRIN3_S32, and MAP4_S696, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminophospholipid transport activity versus SRSF9_S204 in LUAD (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SRSF9_S204 →	-0.430	-0.055	.004	.001	3	6
LSCC	GPRIN3_S32 →	+0.619	+0.066	<.001	<.001	3	6
HNSC	MAP4_S696 →	-0.755	-0.123	<.001	<.001	3	6
PDAC	NAXD →	+0.293	+0.070	.002	<.001	3	6
GBM	NCOA7 →	+0.444	+0.070	<.001	<.001	3	6
GBM	NCOA7_S89 →	+0.471	+0.074	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015917 vs SRSF9_S204 — LUAD

Explore this scatter interactively →