Aminophospholipid transport

Across TCGA patient cohorts, RNA activity of the Aminophospholipid transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRC5A, MIR223HG, and LYSMD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminophospholipid transport activity versus GPRC5A in OV (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GPRC5A →	+1.533	+0.859	.003	<.001	3	3
LSCC	MIR223HG →	+1.037	+0.244	<.001	<.001	3	3
LSCC	LYSMD2 →	+0.342	+0.156	.001	.007	3	3
LSCC	ANKRD22 →	+0.563	+0.168	.005	.003	3	3
LSCC	IFIT5 →	+0.458	+0.176	<.001	.003	3	3
LSCC	P2RY13 →	+0.610	+0.261	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015917 vs GPRC5A — OV

Explore this scatter interactively →