Aminophospholipid transport

Across TCGA cell cohorts, RNA activity of the Aminophospholipid transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIGD2A, CDCA3, and BCL7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HIGD2A grouped by Aminophospholipid transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HIGD2A →	-0.801	-1.147	.006	.002	3	5
OESOPHAGUS	CDCA3 →	-1.098	-0.664	<.001	.002	3	5
CNS	BCL7A →	+0.972	+0.831	<.001	.001	3	4
LUNG_NSCLC_LUAD	TGM2 →	-2.914	-0.798	.001	.007	3	4
OVARY	FLT3LG →	-1.184	-0.749	<.001	.009	3	4
BLOOD_Lymphoma	VPS37C →	+0.961	+1.861	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HIGD2A by Aminophospholipid transport activity — OVARY

Explore this box plot interactively →