Aminophospholipid transport

Across TCGA cell cohorts, RNA activity of the Aminophospholipid transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB2, FAM174A, and FNDC3B, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminophospholipid transport activity versus SCARB2 in SKIN (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SCARB2 →	+1.460	+0.836	<.001	.009	3	12
BONE	FAM174A →	+1.391	+1.144	.005	.002	3	6
BONE	FNDC3B →	+2.021	+1.528	<.001	<.001	3	6
LUNG_NSCLC_LUAD	NPTN →	+0.838	+0.877	<.001	<.001	3	6
OESOPHAGUS	GDPGP1 →	+1.202	+1.225	<.001	.004	3	5
BONE	CD276 →	+1.257	+1.054	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015917 vs SCARB2 — SKIN

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