Long-chain fatty acid import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Long-chain fatty acid import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD36, ITGA7, and PLIN4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid import across plasma membrane activity versus CD36 in OV (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD36 →	+0.910	+0.070	<.001	<.001	3	7
BRCA	ITGA7 →	+1.017	+0.056	<.001	<.001	3	7
BRCA	PLIN4 →	+1.714	+0.059	<.001	<.001	3	7
LSCC	ZW10 →	-0.146	-0.070	.004	<.001	3	6
BRCA	C2 →	+0.399	+0.043	.002	.002	3	6
COAD	C8G →	+0.421	+0.042	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015911 vs CD36 — OV

Explore this scatter interactively →