Long-chain fatty acid import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Long-chain fatty acid import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF12A, SLC20A1, and CCT5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNFRSF12A grouped by Long-chain fatty acid import across plasma membrane-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TNFRSF12A →	-1.541	-1.263	.002	.006	3	5
SOFT_TISSUE	SLC20A1 →	-1.729	-1.477	.001	.007	2	5
BREAST	CCT5 →	-0.655	-0.672	.001	.005	3	4
LARGE_INTESTINE	AZIN1 →	-0.815	-1.419	<.001	<.001	3	4
SOFT_TISSUE	LMO7 →	-3.268	-1.625	.002	<.001	3	4
LUNG_SCLC	PFKFB1 →	-0.355	-1.084	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNFRSF12A by Long-chain fatty acid import across plasma membrane activity — SOFT_TISSUE

Explore this box plot interactively →