Long-chain fatty acid import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Long-chain fatty acid import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRAP2, TMEM205, and TAS2R8, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid import across plasma membrane activity versus GRAP2 in BLOOD_Leukemia (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GRAP2 →	+5.980	+1.782	.005	<.001	2	2
LUNG_SCLC	TMEM205 →	+1.345	+1.918	.006	<.001	2	2
LUNG_SCLC	TAS2R8 →	+0.050	+1.880	.006	<.001	2	2
LUNG_SCLC	HP1BP3 →	+0.576	+1.880	.002	<.001	2	2
LUNG_SCLC	FBLN7 →	+2.684	+1.880	.006	<.001	2	2
BLOOD_Leukemia	FOXB1 →	+3.140	+1.743	<.001	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015911 vs GRAP2 — BLOOD_Leukemia

Explore this scatter interactively →