Fatty acid transport

Across TCGA patient cohorts, RNA activity of the Fatty acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAV1, QKI, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid transport activity versus CAV1 in GBM (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CAV1 →	+0.795	+0.034	<.001	.003	3	8
BRCA	QKI →	+0.259	+0.023	.003	.003	3	8
OV	RSU1 →	+0.398	+0.024	<.001	<.001	3	7
GBM	TLN1 →	+0.418	+0.052	<.001	<.001	3	7
OV	ZYX_S143 →	+1.073	+0.015	.002	.008	3	7
OV	CAVIN3 →	+0.690	+0.016	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015908 vs CAV1 — GBM

Explore this scatter interactively →