Fatty acid transport

Across TCGA patient cohorts, RNA activity of the Fatty acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, F13A1, and MRC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid transport activity versus IRS2 in LUAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IRS2 →	+0.999	+0.255	<.001	<.001	3	6
GBM	F13A1 →	+1.316	+0.199	<.001	<.001	3	6
GBM	MRC1 →	+1.106	+0.188	<.001	<.001	3	6
UCEC	ETV1 →	+0.880	+0.242	.002	.006	3	6
GBM	COL8A1 →	+1.622	+0.205	<.001	<.001	3	6
COAD	DNAJC3 →	+0.455	+0.157	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015908 vs IRS2 — LUAD

Explore this scatter interactively →