Fatty acid transport

Across TCGA cell cohorts, RNA activity of the Fatty acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP13, MOSPD3, and ZNF644, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid transport activity versus USP13 in LARGE_INTESTINE (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP13 →	-1.349	-0.223	.001	.005	3	5
BLOOD_Leukemia	MOSPD3 →	-0.951	-0.158	<.001	.007	3	4
KIDNEY	ZNF644 →	+0.504	+0.276	.007	.001	3	4
KIDNEY	MTF2 →	+0.731	+0.296	<.001	.001	3	4
KIDNEY	ARHGAP35 →	+1.439	+0.321	.005	.001	3	4
BREAST	WDR26 →	+0.868	+0.279	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015908 vs USP13 — LARGE_INTESTINE

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