Cobalamin transport

Across TCGA patient cohorts, RNA activity of the Cobalamin transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are L2HGDH, GMPR2, and RCN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cobalamin transport activity versus L2HGDH in CCRCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	L2HGDH →	+0.316	+0.074	<.001	<.001	3	6
CCRCC	GMPR2 →	+0.341	+0.087	<.001	<.001	3	6
LUAD	RCN1 →	-0.338	-0.071	.004	.001	3	5
LSCC	BAG5 →	+0.226	+0.070	.004	.003	2	6
CCRCC	TPPP →	+0.585	+0.081	<.001	<.001	3	5
CCRCC	NDRG2 →	+0.287	+0.100	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015889 vs L2HGDH — CCRCC

Explore this scatter interactively →