Cobalamin transport

Across TCGA cell cohorts, RNA activity of the Cobalamin transport pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC41A3, TDP1, and MAPK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cobalamin transport activity versus SLC41A3 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SLC41A3 →	-0.655	-1.603	.007	<.001	3	5
CNS	TDP1 →	-0.597	-1.592	.005	<.001	3	5
SOFT_TISSUE	MAPK3 →	-1.140	-1.498	.008	.001	3	4
BLOOD_Leukemia	C22orf39 →	-0.914	-1.095	<.001	<.001	3	4
BLOOD_Leukemia	PPP2R5C →	-0.635	-1.366	<.001	<.001	3	4
BLOOD_Lymphoma	PANK1 →	-1.746	-1.336	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015889 vs SLC41A3 — UPPER_AERODIGESTIVE_TRACT

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