Thiamine transport

Across TCGA patient cohorts, RNA activity of the Thiamine transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCO2, SVIL_S1422, and TMSB10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thiamine transport activity versus SCO2 in PDAC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SCO2 →	+0.340	+0.071	<.001	.004	3	6
HNSC	SVIL_S1422 →	-0.814	-0.121	.004	.007	3	5
BRCA	TMSB10 →	-0.410	-0.075	.001	.004	3	5
BRCA	SLC25A35 →	+0.741	+0.083	<.001	<.001	3	5
GBM	MTARC2 →	+0.403	+0.053	.009	.004	3	5
BRCA	PCCB →	+0.406	+0.067	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015888 vs SCO2 — PDAC

Explore this scatter interactively →