Thiamine transport

Across TCGA patient cohorts, RNA activity of the Thiamine transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC44A4, RNU2-32P, and CPE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thiamine transport activity versus SLC44A4 in OV (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC44A4 →	+1.103	+0.559	.001	.005	2	5
LUAD	RNU2-32P →	+0.090	+0.652	.005	.004	3	3
PDAC	CPE →	-0.593	-0.703	.004	.008	3	3
PDAC	CCRL2 →	+0.347	+0.700	.001	<.001	3	3
PDAC	SLC40A1 →	+0.639	+0.707	.002	.005	3	3
UCEC	RTN4RL1 →	-0.723	-0.685	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015888 vs SLC44A4 — OV

Explore this scatter interactively →