Heme transport

Across TCGA patient cohorts, RNA activity of the Heme transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BAZ2A, GMIP, and PTPN6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heme transport activity versus BAZ2A in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BAZ2A →	+0.247	+0.076	<.001	<.001	3	5
LSCC	GMIP →	+0.239	+0.050	.002	.005	3	5
PDAC	PTPN6 →	+0.188	+0.043	.002	.007	3	5
HNSC	NADK_S46 →	+0.355	+0.039	.002	.006	3	5
GBM	STX11 →	+0.439	+0.035	<.001	<.001	3	4
CCRCC	TRAF3IP3 →	+0.433	+0.039	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015886 vs BAZ2A — UCEC

Explore this scatter interactively →