Heme transport

Across TCGA patient cohorts, RNA activity of the Heme transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R16B, ZIK1, and ZNF835, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heme transport activity versus PPP1R16B in GBM (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP1R16B →	-0.891	-0.125	.008	<.001	3	5
CCRCC	ZIK1 →	-0.582	-0.263	.001	.007	3	5
GBM	ZNF835 →	-0.390	-0.110	.006	.002	3	4
LSCC	PTTG2 →	-0.308	-0.124	.002	.001	3	4
PDAC	TMEM131L →	-0.291	-0.561	.002	.006	3	3
GBM	DEPDC1P1 →	-0.835	-0.189	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015886 vs PPP1R16B — GBM

Explore this scatter interactively →