Heme transport

Across TCGA cell cohorts, RNA activity of the Heme transport pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAP1, ZNF788P, and TLN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAP1 grouped by Heme transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TRAP1 →	+0.132	+0.072	.005	.005	3	5
BREAST	ZNF788P →	+0.127	+0.100	<.001	.002	3	5
PANCREAS	TLN1 →	-0.291	-0.096	.003	.004	3	5
URINARY_TRACT	ZCCHC3 →	-0.322	-0.131	.008	.004	3	5
UPPER_AERODIGESTIVE_TRACT	HMBS →	-0.180	-0.158	.001	.008	3	5
SOFT_TISSUE	GZF1 →	+0.264	+0.163	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAP1 by Heme transport activity — STOMACH

Explore this box plot interactively →