Heme transport

Across TCGA cell cohorts, RNA activity of the Heme transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGRMC2, GPSM3, and COPS4, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heme transport activity versus PGRMC2 in LARGE_INTESTINE (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PGRMC2 →	+1.007	+0.175	.001	.005	3	11
LUNG_SCLC	GPSM3 →	+2.270	+0.237	<.001	.001	3	5
OVARY	COPS4 →	+0.641	+0.160	.006	.004	1	7
LUNG_NSCLC_LUAD	PDLIM5 →	+0.984	+0.147	<.001	<.001	3	5
BONE	ATL3 →	+1.440	+0.261	.007	.001	3	5
LUNG_NSCLC_LUAD	ARFGAP3 →	+0.754	+0.175	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015886 vs PGRMC2 — LARGE_INTESTINE

Explore this scatter interactively →