Folic acid transport

Across TCGA patient cohorts, RNA activity of the Folic acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MPRIP_S993, TSC22D3, and RRP9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid transport activity versus MPRIP_S993 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MPRIP_S993 →	+0.661	+0.113	.002	<.001	3	5
OV	TSC22D3 →	+0.470	+0.054	.001	.005	3	5
LSCC	RRP9 →	-0.219	-0.073	.001	<.001	3	5
LSCC	TBL3 →	-0.256	-0.110	<.001	<.001	3	5
GBM	TNS1_S1588 →	+0.851	+0.100	<.001	<.001	3	5
LSCC	UTP14A →	-0.255	-0.082	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015884 vs MPRIP_S993 — LSCC

Explore this scatter interactively →