Folic acid transport

Across TCGA patient cohorts, RNA activity of the Folic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP2, FOLR1, and CYSTM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid transport activity versus LRP2 in BRCA (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRP2 →	+1.606	+0.451	<.001	<.001	3	4
LSCC	FOLR1 →	+1.056	+0.469	<.001	<.001	3	3
CCRCC	CYSTM1 →	+0.398	+0.245	<.001	<.001	3	3
LSCC	SFTPA1 →	+2.560	+0.534	<.001	<.001	3	3
LSCC	RAB17 →	+0.703	+0.485	.002	<.001	2	4
LSCC	FLRT3 →	+0.957	+0.561	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015884 vs LRP2 — BRCA

Explore this scatter interactively →