Carnitine transport

Across TCGA patient cohorts, RNA activity of the Carnitine transport pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A5, SLC22A4, and SLC16A9, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carnitine transport activity versus SLC22A5 in MESO (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	SLC22A5 →	+1.036	+0.073	<.001	<.001	3	24
KIRC	SLC22A4 →	+1.290	+0.110	<.001	<.001	3	23
KIRC	SLC16A9 →	+1.780	+0.085	<.001	<.001	3	20
KIRC	MIR3936HG →	+0.977	+0.101	<.001	<.001	3	19
READ	ENTPD5 →	+0.966	+0.057	<.001	<.001	3	16
LIHC	TBCB →	-0.496	-0.040	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015879 vs SLC22A5 — MESO

Explore this scatter interactively →