Carnitine transport

Across TCGA patient cohorts, RNA activity of the Carnitine transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUBPL, PPP1R18_S368, and CHDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carnitine transport activity versus NUBPL in COAD (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NUBPL →	+0.722	+0.053	<.001	<.001	3	6
UCEC	PPP1R18_S368 →	-0.569	-0.104	.003	.003	3	6
BRCA	CHDH →	+0.690	+0.069	<.001	<.001	3	6
OV	HIBCH →	+0.395	+0.059	.003	.001	3	6
BRCA	ANLN →	-0.639	-0.074	<.001	<.001	3	6
CCRCC	P3H1 →	-0.389	-0.122	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015879 vs NUBPL — COAD

Explore this scatter interactively →