Norepinephrine transport

Across TCGA patient cohorts, RNA activity of the Norepinephrine transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C19orf47, RERE_S642, and DSP_S1078, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Norepinephrine transport activity versus C19orf47 in CCRCC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C19orf47 →	-0.233	-0.048	.007	<.001	3	5
GBM	RERE_S642 →	-0.380	-0.078	.004	.001	3	5
HNSC	DSP_S1078 →	+0.927	+0.058	<.001	.004	3	4
LSCC	FAF1_S582 →	-0.384	-0.044	<.001	<.001	3	4
LSCC	HSPB1 →	+0.514	+0.039	.002	.001	3	4
UCEC	METAP1 →	+0.214	+0.057	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015874 vs C19orf47 — CCRCC

Explore this scatter interactively →