Norepinephrine transport

Across TCGA patient cohorts, RNA activity of the Norepinephrine transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLNRD1, RALGPS2, and SNCA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Norepinephrine transport activity versus TLNRD1 in OV (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TLNRD1 →	-0.477	-0.778	.001	.004	3	3
PDAC	RALGPS2 →	-0.284	-0.281	.002	.009	3	3
GBM	SNCA →	+0.783	+0.576	.001	.002	3	3
GBM	PTPN5 →	+1.520	+0.786	<.001	<.001	3	3
GBM	RND3 →	-0.770	-0.479	.001	.007	3	3
GBM	CPLX2 →	+2.017	+0.790	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015874 vs TLNRD1 — OV

Explore this scatter interactively →