Dopamine transport

Across TCGA patient cohorts, RNA activity of the Dopamine transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALD1_S131, RPS3A, and SEC14L2_T401, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine transport activity versus CALD1_S131 in BRCA (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CALD1_S131 →	-0.559	-0.042	.002	.001	3	5
GBM	RPS3A →	-0.222	-0.062	<.001	.001	3	4
GBM	SEC14L2_T401 →	+0.421	+0.057	<.001	<.001	3	4
LUAD	SNCG →	+1.104	+0.051	<.001	<.001	3	4
GBM	SNCG_S124 →	+0.975	+0.077	<.001	<.001	3	4
GBM	SYN1 →	+0.777	+0.065	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015872 vs CALD1_S131 — BRCA

Explore this scatter interactively →