Dopamine transport

Across TCGA patient cohorts, RNA activity of the Dopamine transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, FGD2, and GJB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine transport activity versus SLC2A1 in LSCC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC2A1 →	-0.933	-0.157	.001	<.001	3	5
LSCC	FGD2 →	+0.554	+0.173	.007	.003	2	6
LSCC	GJB2 →	-1.314	-0.184	<.001	<.001	3	5
GBM	SNCG →	+1.412	+0.967	<.001	<.001	3	5
CCRCC	GCSIR →	+0.039	+0.119	.004	.001	3	5
GBM	SNAI3 →	+0.425	+0.748	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015872 vs SLC2A1 — LSCC

Explore this scatter interactively →