Dopamine transport

Across TCGA cell cohorts, RNA activity of the Dopamine transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF12, PTPN20, and TCP11L1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine transport activity versus ARHGEF12 in OESOPHAGUS (Pearson r = 0.97).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ARHGEF12 →	+1.076	+1.546	<.001	<.001	3	2
OESOPHAGUS	PTPN20 →	-2.143	-1.546	<.001	<.001	3	2
OESOPHAGUS	TCP11L1 →	+1.185	+1.500	.006	.001	3	2
OESOPHAGUS	KLHL11 →	-0.403	-1.546	.001	<.001	3	2
OESOPHAGUS	C8orf33 →	+0.793	+1.546	.002	<.001	3	2
CNS	NAT9 →	+1.205	+1.855	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015872 vs ARHGEF12 — OESOPHAGUS

Explore this scatter interactively →