Choline transport

Across TCGA cell cohorts, RNA activity of the Choline transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASA2, ZNF713, and DPYS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RASA2 grouped by Choline transport-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RASA2 →	-1.050	-2.213	.004	<.001	3	4
STOMACH	ZNF713 →	-1.121	-0.966	.005	.008	3	4
OVARY	DPYS →	-0.078	-1.134	<.001	<.001	3	4
STOMACH	CNIH2 →	-1.107	-0.698	.008	.007	3	4
BLOOD_Lymphoma	CRTC1 →	-1.102	-2.191	.003	<.001	3	3
BLOOD_Lymphoma	SIGLEC16 →	-0.120	-2.385	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RASA2 by Choline transport activity — BLOOD_Lymphoma

Explore this box plot interactively →