ADP transport

Across TCGA patient cohorts, RNA activity of the ADP transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SULF2, TBC1D2B, and CD276, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ADP transport activity versus SULF2 in PDAC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SULF2 →	-0.392	-0.044	.001	.001	3	4
HNSC	TBC1D2B →	-0.244	-0.092	<.001	<.001	3	4
PDAC	CD276 →	-0.328	-0.045	<.001	<.001	3	4
LSCC	CGN_S338 →	+0.556	+0.045	.008	.003	3	4
LSCC	DVL3 →	-0.204	-0.049	<.001	<.001	3	4
PDAC	SH3BGRL2 →	+0.312	+0.045	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015866 vs SULF2 — PDAC

Explore this scatter interactively →