ADP transport

Across TCGA cell cohorts, RNA activity of the ADP transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A24, DNASE1L1, and CD68, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ADP transport activity versus SLC25A24 in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC25A24 →	+2.615	+0.263	.002	<.001	3	9
PANCREAS	DNASE1L1 →	+1.224	+0.095	<.001	.001	3	6
KIDNEY	CD68 →	+1.831	+0.126	.001	.002	3	6
KIDNEY	ADM →	+1.840	+0.135	.003	<.001	3	6
LUNG_SCLC	SLC25A43 →	+1.954	+0.206	<.001	.001	3	6
SKIN	MICAL2 →	+2.579	+0.136	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015866 vs SLC25A24 — LIVER

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