Purine nucleotide transport

Across TCGA patient cohorts, RNA activity of the Purine nucleotide transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCDC88B_S597, SEPTIN1_S206, and WDFY4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleotide transport activity versus CCDC88B_S597 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCDC88B_S597 →	+0.868	+0.053	<.001	<.001	3	6
BRCA	SEPTIN1_S206 →	+0.755	+0.026	<.001	.001	3	6
LSCC	WDFY4 →	+0.431	+0.046	<.001	<.001	3	6
BRCA	CORO1A →	+0.594	+0.032	<.001	<.001	3	6
LSCC	DOCK8 →	+0.478	+0.051	<.001	<.001	3	6
GBM	ITSN2 →	+0.189	+0.025	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015865 vs CCDC88B_S597 — LSCC

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