Purine nucleotide transport

Across TCGA cell cohorts, RNA activity of the Purine nucleotide transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8B3, WFS1, and LIME1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP8B3 grouped by Purine nucleotide transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATP8B3 →	-2.312	-1.064	<.001	.004	3	6
UPPER_AERODIGESTIVE_TRACT	WFS1 →	-1.292	-1.040	.005	.005	3	5
BLOOD_Myeloma	LIME1 →	-2.322	-1.177	.001	.006	3	4
LUNG_SCLC	IRF6 →	+3.185	+1.082	.001	.004	3	4
LUNG_SCLC	MSRB3 →	-3.827	-1.121	<.001	.002	3	4
LUNG_SCLC	KDELR3 →	-2.791	-1.469	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP8B3 by Purine nucleotide transport activity — LUNG_SCLC

Explore this box plot interactively →