Purine nucleotide transport

Across TCGA cell cohorts, RNA activity of the Purine nucleotide transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD47, UBA7, and SEMA4F, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleotide transport activity versus CD47 in OVARY (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CD47 →	+1.918	+0.237	.002	<.001	3	10
OESOPHAGUS	UBA7 →	+1.460	+0.244	<.001	.008	2	9
LIVER	SEMA4F →	+2.764	+0.332	.003	.007	3	7
CNS	FAM161B →	+0.438	+0.212	.004	.003	3	7
CNS	EXOC5 →	+0.792	+0.309	.002	<.001	3	7
LIVER	COPZ2 →	+2.931	+0.348	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015865 vs CD47 — OVARY

Explore this scatter interactively →