Pyrimidine nucleoside transport

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RGS10, GALNT6, and VASH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside transport activity versus RGS10 in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RGS10 →	+0.377	+0.091	<.001	<.001	3	4
BRCA	GALNT6 →	+0.907	+0.076	<.001	<.001	3	4
GBM	VASH1 →	+0.269	+0.055	.006	.006	3	4
BRCA	AGR2 →	+0.871	+0.063	<.001	.003	3	4
PDAC	ARRB1 →	+0.258	+0.087	<.001	<.001	3	3
PDAC	RIPK3_S339 →	+0.392	+0.053	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015864 vs RGS10 — UCEC

Explore this scatter interactively →