Pyrimidine nucleoside transport

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01127, CXCL10, and NR1H3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside transport activity versus LINC01127 in LUAD (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC01127 →	-0.311	-0.569	.005	.002	3	4
UCEC	CXCL10 →	+2.140	+0.273	<.001	.003	3	4
LSCC	NR1H3 →	+0.629	+0.325	<.001	.001	3	4
PDAC	PTPRB →	-0.386	-0.317	.002	<.001	3	4
CCRCC	MDFI →	-0.365	-0.448	.009	.006	3	4
CCRCC	LDLRAD2 →	-0.201	-0.476	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015864 vs LINC01127 — LUAD

Explore this scatter interactively →