Pyrimidine nucleoside transport

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MNAT1, DPF2, and CRAMP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MNAT1 grouped by Pyrimidine nucleoside transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MNAT1 →	-0.701	-1.069	.001	.005	3	4
LUNG_NSCLC_LUAD	DPF2 →	-0.673	-0.969	.006	.006	3	4
SOFT_TISSUE	CRAMP1 →	-0.852	-0.674	<.001	.008	3	4
LUNG_NSCLC_LUAD	QRICH1 →	-0.479	-0.882	.004	.003	3	4
UPPER_AERODIGESTIVE_TRACT	EIF2AK4 →	-0.869	-1.423	.005	<.001	3	4
OVARY	IPP →	-0.599	-1.320	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MNAT1 by Pyrimidine nucleoside transport activity — STOMACH

Explore this box plot interactively →