Purine nucleoside transmembrane transport

Across TCGA patient cohorts, RNA activity of the Purine nucleoside transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2K4, TBC1D4_S262, and ITPR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside transmembrane transport activity versus MAP2K4 in HNSC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAP2K4 →	-0.168	-0.053	<.001	.002	3	4
LUAD	TBC1D4_S262 →	+0.456	+0.087	.002	.001	3	4
UCEC	ITPR2 →	-0.556	-0.098	<.001	<.001	3	3
UCEC	LRIG1 →	+0.534	+0.100	.002	.002	3	3
UCEC	PRKCQ_S323 →	-0.670	-0.080	.003	.003	3	3
GBM	RECQL →	-0.249	-0.092	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015860 vs MAP2K4 — HNSC

Explore this scatter interactively →