Purine nucleoside transmembrane transport

Across TCGA patient cohorts, RNA activity of the Purine nucleoside transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC1A, C7, and AOX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside transmembrane transport activity versus CLEC1A in OV (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLEC1A →	-0.467	-0.691	.001	.001	3	4
PDAC	C7 →	-2.022	-0.151	.003	.005	3	3
PDAC	AOX1 →	-1.577	-0.155	.003	.004	3	3
OV	CPVL →	-1.070	-0.847	.001	.001	3	3
UCEC	ACTA2 →	-2.115	-0.268	.002	.004	3	3
UCEC	ACTG2 →	-2.556	-0.295	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015860 vs CLEC1A — OV

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