Purine nucleoside transmembrane transport

Across TCGA cell cohorts, RNA activity of the Purine nucleoside transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A26, SLC28A3, and SLC29A2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A26 grouped by Purine nucleoside transmembrane transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC25A26 →	-0.346	-1.666	<.001	<.001	3	9
OVARY	SLC28A3 →	-0.353	-1.521	.001	.001	2	8
LUNG_NSCLC_LUSC	SLC29A2 →	-0.281	-1.511	.003	.002	2	7
LUNG_SCLC	CELSR1 →	-0.416	-1.593	.009	<.001	3	5
SOFT_TISSUE	NFIX →	-0.416	-1.585	.005	.003	2	6
LUNG_NSCLC_LUSC	SLC29A1 →	-0.255	-1.497	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A26 by Purine nucleoside transmembrane transport activity — PANCREAS

Explore this box plot interactively →