Nucleoside transport

Across TCGA patient cohorts, RNA activity of the Nucleoside transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOC1, LDB3, and MSC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside transport activity versus APOC1 in CCRCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	APOC1 →	+0.787	+0.546	<.001	.001	3	5
HNSC	LDB3 →	-1.073	-0.227	.008	.001	2	4
PDAC	MSC →	+0.794	+0.298	<.001	<.001	3	3
PDAC	IGLL5 →	+0.651	+0.245	.008	.009	3	3
CCRCC	MSRB3 →	-0.578	-0.765	.002	<.001	3	3
CCRCC	ANKRD35 →	-0.280	-0.691	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015858 vs APOC1 — CCRCC

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