Adenine transport

Across TCGA cell cohorts, RNA activity of the Adenine transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC10A3, ADGRE5, and TRDMT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC10A3 grouped by Adenine transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SLC10A3 →	-1.292	-2.167	.002	<.001	3	5
LUNG_NSCLC_LUSC	ADGRE5 →	-2.723	-1.941	<.001	<.001	3	4
LUNG_NSCLC_LUSC	TRDMT1 →	-1.033	-1.817	.008	.002	3	4
LUNG_NSCLC_LUSC	RALB →	-1.446	-1.689	.009	.002	3	4
LUNG_NSCLC_LUSC	KLF6 →	-2.754	-1.563	.001	.003	3	4
LUNG_NSCLC_LUSC	STK10 →	-1.668	-2.213	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC10A3 by Adenine transport activity — BLOOD_Myeloma

Explore this box plot interactively →