Adenine transport

Across TCGA cell cohorts, RNA activity of the Adenine transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNTA, HGSNAT, and IKBKB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenine transport activity versus FNTA in BREAST (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FNTA →	+0.992	+0.171	<.001	<.001	3	7
BLOOD_Leukemia	HGSNAT →	+1.644	+0.260	<.001	<.001	3	6
LUNG_SCLC	IKBKB →	+1.259	+0.175	.005	.002	3	5
BREAST	HOOK3 →	+1.317	+0.207	.001	.001	3	5
BREAST	SLC20A2 →	+1.227	+0.222	.001	<.001	3	5
BREAST	TM2D2 →	+0.924	+0.149	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015853 vs FNTA — BREAST

Explore this scatter interactively →