Spermidine transport

Across TCGA patient cohorts, RNA activity of the Spermidine transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR10, TRAJ45, and TRAJ24, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermidine transport activity versus TLR10 in LSCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TLR10 →	+1.684	+0.326	.003	<.001	3	2
LSCC	TRAJ45 →	+2.866	+0.363	.005	<.001	3	2
LSCC	TRAJ24 →	+1.909	+0.436	.004	.002	3	2
LSCC	TMX2 →	-0.376	-0.306	.006	.004	3	2
LSCC	LY86-AS1 →	+0.429	+0.376	.009	.009	3	2
LSCC	AP4B1-AS1 →	+0.363	+0.326	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015848 vs TLR10 — LSCC

Explore this scatter interactively →