Polyamine transport

Across TCGA patient cohorts, RNA activity of the Polyamine transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PABPC1L, PTCD1, and NIT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyamine transport activity versus PABPC1L in GBM (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PABPC1L →	+0.877	+0.192	<.001	<.001	3	3
BRCA	PTCD1 →	+0.189	+0.400	.005	.007	2	4
BRCA	NIT2 →	+0.223	+0.322	.009	.007	1	5
BRCA	GTPBP3 →	+0.382	+0.381	.001	.001	3	3
BRCA	CHCHD2P6 →	+0.936	+0.385	.005	.007	3	3
BRCA	EFL1P1 →	+0.213	+0.358	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015846 vs PABPC1L — GBM

Explore this scatter interactively →